Before you take Fludara

Before you take Fludara

When you must not be given it

Do not have any Fludara if you have an allergy to:any medicine containing fludarabineany of the ingredients listed at the end of this leaflet.Some of the symptoms of an allergic reaction may include:shortness of breathwheezing or difficulty breathingswelling of the face, lips, tongue or other parts of the bodyrash, itching or hives on the skinDo not have Fludara if youare pregnantare breast-feedingyour red blood cell count is low because of a type of anaemia (haemolytic anaemia)have severe kidney problemsDo not take this medicine if you are pregnant.It may affect your developing baby if you take it during pregnancy.Do not breast-feed if you are taking this medicine.It is possible that your baby may be affected if you breastfeed.If you are not sure whether you should start taking this medicine, talk to your doctor.

Before you take it

Tell your doctor if you have allergies to any other medicines, foods, preservatives or dyes.Tell your doctor if you have or have had any of the following medical conditions:low protein in the blood (hypoalbuminaemia). Your doctor will have told you if you have feel very unwell, have unusual bruising, more bleeding than usual after injury, or if you seem to be catching a lot of infectionspoor kidney functionenlarged liver or spleen, reduced liver functionskin cancerIf you have or have had skin cancer it may worsen or flare up again while you take Fludara or afterwards.Tell your doctor if you are over 75 years of age.Your doctor will administer Fludara to you with caution and monitor your closely.Tell your doctor if the person is below 18 years of age.It is not recommended to give this medicine to a child under the age of 18 years.Tell your doctor if you are pregnant or plan to become a parent.Men and women who may still be fertile must use a reliable form of contraception during treatment and for at least 6 months after stopping Fludara therapy. It is not known whether Fludara decreases your fertility. Your doctor can discuss with you the risks and benefits involved.If you have not told your doctor about any of the above, tell him/her before you start taking Fludara.

Taking other medicines

Tell your doctor or pharmacist if you are taking any other medicines, including any that you get without a prescription from your pharmacy, supermarket or health food shop.Some medicines and Fludara may interfere with each other. These include:(pentostatin (deoxycoformycin) also used to treat B-CLL. Taking these two drugs together can lead severe lung problems.cytarabine (Ara-C) used to treat chronic lymphatic leukaemiadipyridamole, used to prevent excessive blood clotting, or other similar drugslive viral vaccines. It is recommended that patients do not receive live viral vaccines during and after treatment with Fludara.These medicines may be affected by Fludara or may affect how well it works. You may need different amounts of your medicines, or you may need to take different medicines.Your doctor may have more information on medicines to be careful with or avoid while taking this medicine.

How to take Fludara Oral

Fludara should be administered under the supervision of a qualified physician experienced in the use of cancer therapy. The dose you should take depends on your body surface area. This is measured in square metres (m²), and is worked out by the doctor from your height and weight.Follow all directions given to you by your doctor or pharmacist carefully.They may differ from the information contained in this leaflet.If you do not understand the instructions on the box/bottle, ask your doctor or pharmacist for help.

How much to take

The recommended dose is 40mg per square metre of body surface area, once a day. The exact number of tablets you should take is calculated by your doctor. The usual dose is between 3 to 10 tablets once a day.

How to take it

Swallow the tablets whole with a full glass of water. Do not chew or break the tablets.

When to take it

Take the tablets the same time every day.Fludara can be taken either on an empty stomach or together with food.

How long to take it

Take the dose worked out by your doctor once a day for 5 consecutive days.The 5-day-course of treatment will be repeated every 28 days until your doctor has decided that the best effect has been achieved (usually after 6 courses). Your doctor may adjust the dose and number of treatment days.

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