Who should not take IRINOTECAN HCL?

Who should not take IRINOTECAN HCL?


Who should not take IRINOTECAN HCL?

The following conditions are contraindicated with this drug. Check with your physician if you have any of the following:


  • dehydration
  • decreased function of bone marrow
  • anemia
  • decreased blood platelets
  • low levels of a type of white blood cell called neutrophils
  • method of removing waste/poison from blood with dialysis
  • obstruction of a blood vessel by a blood clot
  • a type of inflammation of the lung called interstitial pneumonitis
  • blocked bowels with decreased peristaltic movement
  • liver problems
  • acute inflammation of the pancreas
  • decreased kidney function
  • high amount of bilirubin in the blood
  • diarrhea
  • pregnancy
  • a patient who is producing milk and breastfeeding
  • chronic obstructive pulmonary disease
  • reduced UGT1A1 enzyme activity due to *28 polymorphism
  • sepsis
  • kidney disease with likely reduction in kidney function

Administering IRINOTECAN HCL to Children or the Elderly?

If you are PREGNANT

  • Not Recommended:

If you are NURSING


If you are an adult over 60

  • management or monitoring precaution: General-The starting dose of Irinotecan in patients 70 years and older for the every-3-week-dosage schedule should be 300 mg/m2. The incidence of severe diarrhea and neutropenia is higher in the elderly.

Giving Haloperidol to a child under 12

  • Severe Precaution: Risk of dehydration, hypokalemia, hyponatremia. Efficacy not demonstrated in pediatric trials.

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