BUY CAMPTO (IRINOTECAN) ONLINE

BUY CAMPTO (IRINOTECAN) ONLINE

What is Onivyde (irinotecan) for?

BUY CAMPTO (IRINOTECAN) ONLINE in combination with 5-fluorouracil and leucovorin (two other cancer

medicines^[6,7]) for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease

progression following gemcitabine-based therapy^[1,2,5].

How does Onivyde (irinotecan) work?

The active substance in Onivyde, irinotecan, is a topoisomerase inhibitor.

It blocks an enzyme called topoisomerase I. This enzyme is involved in copying cell DNA, which is needed to make

new cells. By blocking the enzyme, cancer cells are prevented from multiplying and they eventually die. In Onivyde,

irinotecan is contained within tiny fat particles called ‘liposomes’. The liposomes are expected to accumulate within

the tumour and release the medicine slowly over time, thereby allowing it to act for longer.

Is Onivyde (irinotecan) approved?

Onivyde (irinotecan liposome injection or irinotecan hydrochloride trihydrate) was approved for metastatic adenocarcinoma of the pancreas for use in combination with 5-fluorouracil and leucovorin in adults whose cancer has gotten worse despite treatment containing the cancer medicine gemcitabine by:

• Food and Drugs Administration (FDA) (USA) on October 22, 2015
• European Medicines Administration (EMA) (EU) on October 14, 2016^[
• Therpeautic Goods Administration (TGA) (AUS) on December 19, 2016
• Health Canada on October 4, 2017^[9]
• Medsafe (New Zealand) on September 20, 2018^[10]

How do I take Onivyde (irinotecan)?

Note that 1 mL of the EMA approved Onivyde marketed by Baxalta Innovations GmbH contains the

equivalent of 5 mg irinotecan hydrochloride trihydrate (as irinotecan sucrosofate salt in a pegylated

liposomal formulation which corresponds to 4.3 mg/1 mL irinotecan liposome injection^[3]. The

latter is the strength approved by the FDA and TGA^[2,5 ].

The standard EMA dosage (Onivyde (irinotecan hydrochloride trihydrate) 5 mg/mL) is:

• 80 mg/m2 administered by intravenous infusion every 2 weeks followed by 5‑fluorouracil and leucovorin^[3].

The standard FDA dosage (Onivyde ((irinotecan liposome injection) 4.3 mg/mL) is:

• 70 mg/m2 administered by intravenous infusion every 2 weeks followed by 5‑fluorouracil and leucovorin^[2,5].

Complete information about Onivyde (liposomal irinotecan) dosage and administration can be found in the references section.

Note: Consult your doctor for a personalised dosing.

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