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Promethazine is a first-generation antihistamine and antipsychotic used to treat allergies, insomnia, and nausea. It was once widely used as an antipsychotic, although it is generally not used for this purpose now. It has approximately 1/10 the antipsychotic strength of chlorpromazine.  It may also help with some symptoms associated with the common cold and may also be used for sedating people who are agitated or anxious. Promethazine is available by mouth in syrup or tablet dosage forms, as a rectal suppository, or by injection into a muscle.
Common side effects of promethazine include confusion and sleepiness; consumption of alcohol or other sedatives can make these symptoms worse. It is unclear if use of promethazine during pregnancy or breastfeeding is safe for the baby. Use of promethazine is not recommended in those less than two years old, due to potentially negative effects on breathing. Use of promethazine by injection into a vein is not recommended, due to potential skin damage. Promethazine is in the phenothiazine family of medications.
Promethazine was made in the 1940s by a team of scientists from Rhône-Poulenc laboratories. It was approved for medical use in the United States in 1951. It is a generic medication and is available under many brand names globally. In 2018, it was the 150th most commonly prescribed medication in the United States, with more than 4 million prescriptions.